Ma Laboratory

Selected Publications

Wang B, Underwood R, Kamath A, Britain C, McFerrin MB, McLean PJ, Volpicelli-Daley LA, Whitaker RH, Placzek WJ, Becker K, Ma J, Yacoubian TA. 2018. 14-3-3 proteins reduce cell-to-cell transfer and propagation of pathogenic alpha-synuclein. J Neurosci.

Graham SF, Rey NL, Yilmaz A, Kumar P, Madaj Z, Maddens M, Bahado-Singh RO, Becker K, Schulz E, Meyerdirk LK, Steiner JA, Ma J, Brundin P. 2018. Biochemical profiling of the brain and blood metabolome in a mouse model of prodromal Parkinson’s disease reveal distinct metabolic profilesJ Proteome Res.

Wang F, Wang X, Abskharon R, Ma J. 2018. Prion infectivity is encoded exclusively within the structure of proteinase K-resistant fragments of synthetically generated recombinant PrPScActa Neuropathol Commun 6(1):30.

Becker K, Wang X, Vander Stel K, Chu Y, Kordower J, Ma J. 2018. Detecting alpha synuclein seeding activity in formaldehyde-fixed MSA patient tissue by PMCAMol Neurobiol

Sevillano AM, Fernández-Borges N, Younas N, Wang F, R Elezgarai S, Bravo S, Vázquez-Fernández E, Rosa I, Eraña H, Gil D, Veiga S, Vidal E, Erickson-Beltran ML, Guitián E, Silva CJ, Nonno R, Ma J, Castilla J, R Requena J. 2018. Recombinant PrPScshares structural features with brain-derived PrPSc: Insights from limited proteolysisPLoS Pathog 14(1):e1006769.

Wang F, Wang X, Orrú CD, Groveman BR, Surewicz K, Abskharon R, Imamura M, Yokoyama T, Kim YS, Vander Stel KJ, Sinniah K, Priola SA, Surewicz WK, Caughey B, Ma J. 2017. Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity. PLoS Pathog 13(7):e1006491.

Abskharon R, Wang F, Vander Stel KJ, Sinniah K, Ma J. 2016. The role of the unusual threonine string in the conversion of prion protein. Sci Rep 6:38877.

Brundin P, Ma J, Kordower JH. 2016. How strong is the evidence that Parkinson’s disease is a prion disorder? Curr Opin Neurol 29(4):459–466.

Yu G, Deng A, Tang W, Ma J, Yuan C, Ma J. 2016.  Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity. Neurochem Int 96:113–120.

Wang X, McGovern G, Zhang Y, Wang F, Zha L, Jeffrey M, Ma J. 2015. Intraperitoneal infection of wild-type mice with synthetically generated mammalian prionPLoS Pathog 11(7):e1004958. 

Yu G, Liu H, Zhou W, Zhu X, Yu C, Wang N, Zhang Y, Ma J, Zhao Y, Xu Y, Liao L, Ji H, Yuan C, Ma J. 2015. In vivo protein targets for increased quinoprotein adduct formation in aged substantia nigra. Exp Neurol 271:13–24.     

Ma J, Wang F. 2014. Prion disease and the “Protein-only hypothesis”. In Sarah Perrett (Ed) Amyloid in Health & Disease, Essays in Biochemistry, 56:181–191. DOI: 10.1042/bse0560181

Zhang Y, Wang F, Wang X, Zhang Z, Xu Y, Yu G, Yuan C, Ma J. 2014. Comparison of 2 synthetically generated recombinant prionsPrion 8(2):28669.                

Miller MB, Wang DW, Wang F, Noble GP, Ma J, Woods Jr VL, Li S, Supattapone S. 2013. Cofactor molecules induce structural transformation during infectious prion formationStructure 21(11):2061–2068. 

Zhang Z, Zhang Y, Wang F, Wang X, Xu Y, Yang H, Yu G, Yuan C, Ma J. 2013. De novo generation of infectious prions with bacterially expressed recombinant prion proteinFASEB J. 27(12):4768–4775.  

Wang F, Ma J. 2013. Role of lipid in forming an infectious prion? Acta Biochim Biophys Sin (Shanghai) 45(6):485–493.                       

Yu G, Jiang L, Xu Y, Guo H, Liu H, Zhang Y, Yang H, Yuan C, Ma J. 2012. Silencing prion protein in MDA-MB-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuliPLoS One 7(11): e48146. 

Deleault NR, Walsh DJ, Piro JR, Wang F, Wang X, Ma J, Rees JR, Supattapone S. 2012. Cofactor molecules maintain infectious conformation and restrict strain properties in purified prionsProc Natl Acad Sci USA 109(28):E1938–1946.           

Deleault NR, Piro JR, Walsh DJ, Wang F, Ma J, Geoghegan JC, Supattapone S. 2012. Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acidProc Natl Acad Sci USA 109(22):8546–8551.        

Ma J. 2012. The role of cofactors in prion propagation and infectivityPLoS Pathog 8(4):e1002589. 

Wang F, Zhang Z, Wang X, Li J, Zha L, Yuan C, Weissmann C, Ma J. 2012. Genetic informational RNA is not required for recombinant prion infectivityJ Virol86(3):1874–1876.                       

Ma J. 2012. PrP conversion and lipids. In W.-Q. Zou and P. Gambetti (Eds) Prions and Diseases: Volume 1, Physiology and Pathophysiology (107–119). Springer. 

Piro JR, Wang F, Walsh DJ, Rees JR, Ma J, Supattapone S. 2011. Seeding specificity and ultrastructural characteristics of infectious recombinant prionsBiochemistry 50(33):7111–7116            

Wang N, Wang Y, Yu G, Yuan C, Ma J. 2011. Quinoprotein adducts accumulate in the substantia nigra of aged rats and correlate with dopamine-induced toxicity in SH-SY5Y cellsNeurochem Res 36(11):2169–2175.        

Wang F, Wang X, Ma J. 2011. Conversion of bacterially expressed recombinant prion proteinMethods 53(3):208–213.                    

Wang F, Yin S, Wang X, Zha L, Sy M, Ma J. 2010. Role of the highly conserved middle region of PrP in PrP-lipid interactionBiochemistry 49(37):8169-8176.    

Wang F, Wang X, Yuan C, Ma J. 2010. Generating a prion with bacterially expressed recombinant prion proteinScience 327(5869):1132–1135.      

Faas H, Jackson WS, Borkowski A, Wang X, Ma J, Lindquist S, Jasanoff A. 2010. Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion proteinNeuroImage 49(3):2607–2617.      

Yu G, Chen J, Xu Y, Zhu C, Yu H, Liu S, Sha H, Chen J, Xu X, Wu Y, Zhang A, Ma J, Cheng G. 2009. Generation of goats lacking prion proteinMol Reprod Dev76(1):3.

Wang X, Bowers S, Wang F, Pu X, Nelson RJ, Ma J. 2009. Cytoplasmic prion protein induces forebrain neurotoxicityBiochim Biophys Acta 1792(6):555–563.      

Wang F, Yang F, Hu Y, Wang X, Wang X, Jin C, Ma J. 2007. Lipid interaction converts prion protein to a PrPSc-like proteinase K resistant conformation under physiological conditionsBiochemistry 46(23):7045–7053. 

Wang X, Wang F, Arterburn L, Wollmann R, Ma J. 2006. The interaction between cytoplasmic PrP and the hydrophobic lipid core of membrane correlates with neurotoxicityJ Biol Chem 281(19):13478–13484.  

Wang X, Thomas B, Sachdeva R, Arterburn L, Frye L, Hatcher PG, Cornwell DG, Ma J. 2006. Mechanism of quinone toxicity involving arylation and induction of ER stressProc Natl Acad Sci USA 103:3604–3609.