Ma Laboratory

Selected Publications

Wang X, McGovern G, Zhang Y, Wang F, Zha L, Jeffrey M, Ma J. 2015. Intraperitoneal infection of wild-type mice with synthetically generated mammalian prion. PLoS Pathog 11(7):e1004958. doi: 10.1371/journal.ppat.1004958.       PubMed

Yu G, Liu H, Zhou W, Zhu X, Yu C, Wang N, Zhang Y, Ma J, Zhao Y, Xu Y, Liao L, Ji H, Yuan C, Ma J. 2015. In vivo protein targets for increased quinoprotein adduct formation in aged substantia nigra. Exp Neurol 271:13–24.      PubMed

Ma J, Wang F. 2014. Prion disease and the “Protein-only hypothesis”. In Sarah Perrett (Ed) Amyloid in Health & Disease, Essays in Biochemistry, 56:181–191. DOI: 10.1042/bse0560181

Zhang Y, Wang F, Wang X, Zhang Z, Xu Y, Yu G, Yuan C, Ma J. 2014. Comparison of 2 synthetically generated recombinant prions. Prion 8(2).                 PubMed

Miller MB, Wang DW, Wang F, Noble GP, Ma J, Woods Jr VL, Li S, Supattapone S. 2013. Cofactor molecules induce structural transformation during infectious prion formation. Structure 21(11):2061–2068. PubMed

Zhang Z, Zhang Y, Wang F, Wang X, Xu Y, Yang H, Yu G, Yuan C, Ma J. 2013. De novo generation of infectious prions with bacterially expressed recombinant prion protein. FASEB J. 27(12):4768–75.    PubMed

Wang F, Ma J. 2013. Role of lipid in forming an infectious prion? Acta Biochim Biophys Sin (Shanghai) 45(6):485–493.                        PubMed

Yu G, Jiang L, Xu Y, Guo H, Liu H, Zhang Y, Yang H, Yuan C, Ma J. 2012. Silencing prion protein in MDA-MB-435 breast cancer cells leads to pleiotropic cellular responses to cytotoxic stimuli. PLoS One 7(11): e48146. PubMed

Deleault NR, Walsh DJ, Piro JR, Wang F, Wang X, Ma J, Rees JR, Supattapone S. 2012. Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions. Proc Natl Acad Sci USA 109(28):E1938–1946.           PubMed

Deleault NR, Piro JR, Walsh DJ, Wang F, Ma J, Geoghegan JC, Supattapone S. 2012. Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acid. Proc Natl Acad Sci USA 109(22):8546–8551.              PubMed

Ma J. 2012. The role of cofactors in prion propagation and infectivity. PLoS Pathog 8(4):e1002589. Article

Wang F, Zhang Z, Wang X, Li J, Zha L, Yuan C, Weissmann C, Ma J. 2012. Genetic informational RNA is not required for recombinant prion infectivity. J Virol 86(3):1874–1876.                       PubMed 

Ma J. 2012. PrP Conversion and Lipids. In W.-Q. Zou and P. Gambetti (Eds) Prions and Diseases: Volume 1, Physiology and Pathophysiology (107–119). Springer. doi 10.1007/978-1-4614-5305-5_8

Piro JR, Wang F, Walsh DJ, Rees JR, Ma J, Supattapone S. 2011. Seeding specificity and ultrastructural characteristics of infectious recombinant prions. Biochemistry 50(33):7111–7116.             PubMed

Wang N, Wang Y, Yu G, Yuan C, Ma J. 2011. Quinoprotein adducts accumulate in the substantia nigra of aged rats and correlate with dopamine-induced toxicity in SH-SY5Y cells. Neurochem Res 36(11):2169–2175.        PubMed

Wang F, Wang X, Ma J. 2011. Conversion of bacterially expressed recombinant prion protein. Methods 53(3):208–213.                        PubMed

Wang F, Yin S, Wang X, Zha L, Sy M, Ma J. 2010. Role of the highly conserved middle region of PrP in PrP-lipid interaction. Biochemistry 49(37):8169-8176.            PubMed

Wang F, Wang X, Yuan C, Ma J. 2010. Generating a prion with bacterially expressed recombinant prion protein. Science 327(5869):1132–1135.        PubMed

Faas H, Jackson WS, Borkowski A, Wang X, Ma J, Lindquist S, Jasanoff A. 2010. Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion protein. NeuroImage 49(3):2607–2617.      PubMed

Yu G, Chen J, Xu Y, Zhu C, Yu H, Liu S, Sha H, Chen J, Xu X, Wu Y, Zhang A, Ma J, Cheng G. 2009. Generation of goats lacking prion protein. Mol Reprod Dev 76(1):3       PubMed

Wang X, Bowers S, Wang F, Pu X, Nelson RJ, Ma J. 2009. Cytoplasmic prion protein induces forebrain neurotoxicity. Biochim Biophys Acta 1792(6):555–563.      PubMed

Wang F, Yang F, Hu Y, Wang X, Wang X, Jin C, Ma J. 2007. Lipid interaction converts prion protein to a PrPSc-like proteinase K resistant conformation under physiological conditions. Biochemistry 46(23):7045–7053. PubMed

Wang X, Wang F, Arterburn L, Wollmann R, Ma J. 2006. The interaction between cytoplasmic PrP and the hydrophobic lipid core of membrane correlates with neurotoxicity. J Biol Chem 281(19):13478–13484.   PubMed

Wang X, Thomas B, Sachdeva R, Arterburn L, Frye L, Hatcher PG, Cornwell DG, Ma J. 2006. Mechanism of quinone toxicity involving arylation and induction of ER stress. Proc Natl Acad Sci USA 103:3604–3609. PubMed